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Structure of a short-chain dehydrogenase/reductase from Bacillus anthracis.

ABSTRACT: The crystal structure of a short-chain dehydrogenase/reductase from Bacillus anthracis strain `Ames Ancestor' complexed with NADP has been determined and refined to 1.87 Å resolution. The structure of the enzyme consists of a Rossmann fold composed of seven parallel ?-strands sandwiched by three ?-helices on each side. An NADP molecule from an endogenous source is bound in the conserved binding pocket in the syn conformation. The loop region responsible for binding another substrate forms two perpendicular short helices connected by a sharp turn.

SUBMITTER: Hou J 

PROVIDER: S-EPMC3370898 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature

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Structure of a short-chain dehydrogenase/reductase from Bacillus anthracis.

Hou Jing J   Wojciechowska Kamila K   Zheng Heping H   Chruszcz Maksymilian M   Cooper David R DR   Cymborowski Marcin M   Skarina Tatiana T   Gordon Elena E   Luo Haibin H   Savchenko Alexei A   Minor Wladek W  

Acta crystallographica. Section F, Structural biology and crystallization communications 20120524 Pt 6

The crystal structure of a short-chain dehydrogenase/reductase from Bacillus anthracis strain `Ames Ancestor' complexed with NADP has been determined and refined to 1.87 Å resolution. The structure of the enzyme consists of a Rossmann fold composed of seven parallel β-strands sandwiched by three α-helices on each side. An NADP molecule from an endogenous source is bound in the conserved binding pocket in the syn conformation. The loop region responsible for binding another substrate forms two pe  ...[more]

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