Ontology highlight
ABSTRACT:
SUBMITTER: Speese SD
PROVIDER: S-EPMC3371233 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Cell 20120501 4
Localized protein synthesis requires assembly and transport of translationally silenced ribonucleoprotein particles (RNPs), some of which are exceptionally large. Where in the cell such large RNP granules first assemble was heretofore unknown. We previously reported that during synapse development, a fragment of the Wnt-1 receptor, DFrizzled2, enters postsynaptic nuclei where it forms prominent foci. Here we show that these foci constitute large RNP granules harboring synaptic protein transcript ...[more]