Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors.

ABSTRACT:

Background

Elevated serum urate levels can lead to gout and are associated with cardiovascular risk factors. We performed a genome-wide association study to search for genetic susceptibility loci for serum urate and gout and investigated the causal nature of the associations of serum urate with gout and selected cardiovascular risk factors and coronary heart disease (CHD).

Methods and results

Meta-analyses of genome-wide association studies (GWAS) were performed in 5 population-based cohorts of the Cohorts for Heart and Aging Research in Genome Epidemiology consortium for serum urate and gout in 28 283 white participants. The effect of the most significant single-nucleotide polymorphism at all genome-wide significant loci on serum urate was added to create a genetic urate sc

SUBMITTER: Yang Q 

PROVIDER: S-EPMC3371395 | biostudies-literature | 2010 Dec

REPOSITORIES: biostudies-literature