7q21-rs6964587 and breast cancer risk: an extended case-control study by the Breast Cancer Association Consortium.

ABSTRACT:

Background

Using the Breast Cancer Association Consortium, the authors previously reported that the single nucleotide polymorphism 7q21-rs6964587 (AKAP9-M463I) is associated with breast cancer risk. The authors have now assessed this association more comprehensively using 16 independent case-control studies.

Methods

The authors genotyped 14,843 invasive case patients and 19,852 control subjects with white European ancestry and 2595 invasive case patients and 2192 control subjects with Asian ancestry. ORs were estimated by logistic regression, adjusted for study. Heterogeneity in ORs was assessed by fitting interaction terms or by subclassifying case patients and applying polytomous logistic regression.

Results

For white European women, the minor T allele of 7q21-rs696

SUBMITTER: Milne RL 

PROVIDER: S-EPMC3371608 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature