Plasma apolipoprotein levels are associated with cognitive status and decline in a community cohort of older individuals.

ABSTRACT:

Objectives

Apolipoproteins have recently been implicated in the etiology of Alzheimer's disease (AD). In particular, Apolipoprotein J (ApoJ or clusterin) has been proposed as a biomarker of the disease at the pre-dementia stage. We examined a group of apolipoproteins, including ApoA1, ApoA2, ApoB, ApoC3, ApoE, ApoH and ApoJ, in the plasma of a longitudinal community based cohort.

Methods

664 subjects (257 with Mild Cognitive Impairment [MCI] and 407 with normal cognition), mean age 78 years, from the Sydney Memory and Aging Study (MAS) were followed up over two years. Plasma apolipoprotein levels at baseline (Wave 1) were measured using a multiplex bead fluorescence immunoassay technique.

Results

At Wave 1, MCI subjects had lower levels of ApoA1, ApoA2 and ApoH, and h

SUBMITTER: Song F 

PROVIDER: S-EPMC3372509 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature