Structural dynamics and epigenetic modifications of Hoxc loci along the anteroposterior body axis in developing mouse embryos.

ABSTRACT: Hox genes are organized as clusters and specify regional identity along the anteroposterior body axis by sequential expression at a specific time and region during embryogenesis. However, the precise mechanisms underlying the sequential spatio-temporal, collinear expression pattern of Hox genes are not fully understood. Since epigenetic modifications such as chromatin architecture and histone modifications have become crucial mechanisms for highly coordinated gene expressions, we examined such modifications. E14.5 mouse embryos were dissected into three parts along the anteroposterior axis: brain, trunk-anterior, and trunk-posterior. Then, structural changes and epigenetic modifications were analyzed along the Hoxc cluster using chromosome conformation capture and chromatin immunoprecipita

SUBMITTER: Min H 

PROVIDER: S-EPMC3372884 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature