Genetic variation in vascular endothelial growth factor-a and lung function.

ABSTRACT:

Rationale

Given the role of vascular endothelial growth factor (VEGF) in lung development, we hypothesized that polymorphisms in VEGF-A may be associated with lung function.

Objectives

The current study was designed to assess the role of genetic variants in VEGF-A as determinants of airway function from infancy through early adulthood.

Methods

Association between five single-nucleotide polymorphisms (SNPs) in VEGF-A and lung function were assessed longitudinally in two unselected birth cohorts and cross-sectionally among infants. Replication with two SNPs was conducted in adults and children with asthma. We investigated the functionality of the SNP most consistently associated with lung function (rs3025028) using Western blotting to measure the ratio of plasma VEGF-A(

SUBMITTER: Simpson A 

PROVIDER: S-EPMC3373065 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature