Increased levels of BAFF and APRIL related to human active pulmonary tuberculosis.

ABSTRACT:

Background

Despite great efforts to improve diagnosis and treatment, tuberculosis (TB) remains a major health problem worldwide, especially in developing countries. Lack of concrete immune markers is still the obstacle to properly evaluate active TB. Therefore, identification of more validated biomarkers and phenotypic signatures is imperative. In particular, T cell-related biomarkers are more significant.

Methodology

To understand the nature of CD4(+) T cell-derived signatures involved in infection and disease development, we examined and analyzed whole genome expression profiles of purified CD4(+) T cells from healthy individuals (HD), two distinct populations with latent infection (with low or high IFN-γ levels, LTB(L)/LTB(H)) and untreated TB patients. Following, we vali

SUBMITTER: Liu K 

PROVIDER: S-EPMC3373577 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature