Validation of genetic variants associated with early acute rejection in kidney allograft transplantation.

ABSTRACT: Numerous reports have identified genetic variants associated with kidney transplant outcome, but only a few have been validated in subsequent studies. We analyzed the association of 21 previously reported genetic variants associated with acute rejection (AR), in an effort to validate these associations in our kidney transplant population. All recipients (n = 585) received Ab induction, rapid discontinuation of prednisone, and calcineurin inhibitors with either mycophenolate mofetil or sirolimus. Both univariate analysis and logistic regression were used for determining the association between the genotypes and AR. Univariate analysis detected one significant single-nucleotide polymorphism (p = 0.03), rs1801133, within the methylenetetrahydrofolate reductase (MTHFR) gene associated with AR.

SUBMITTER: Oetting WS 

PROVIDER: S-EPMC3374041 | biostudies-literature | 2012 May-Jun

REPOSITORIES: biostudies-literature