Early response of mucosal epithelial cells during Toxoplasma gondii infection.

ABSTRACT: The innate immune response of mucosal epithelial cells during pathogen invasion plays a central role in immune regulation in the gut. Toxoplasma gondii is a protozoan intracellular parasite that is usually transmitted through oral infection. Although much of the information on immunity to T. gondii has come from i.p. infection models, more recent studies have revealed the importance of studying immunity following infection through the natural peroral route. Oral infection studies have identified many of the key players in the intestinal response; however, they have relied on responses detected days to weeks following infection. Much less is known about how the gut epithelial layer senses and reacts during initial contact with the pathogen. Given the importance of epithelial cells during pa

SUBMITTER: Ju CH 

PROVIDER: S-EPMC3374343 | biostudies-literature | 2009 Dec

REPOSITORIES: biostudies-literature