Uncovering potential Drug Targets for Tuberculosis using Protein Networks.

ABSTRACT: The emergence of HIV-TB co-infection and multi-drug resistant strains of Mycobacterium tuberculosis (Mtb) drive the need for new therapeutics against the infectious disease tuberculosis. Among the reported putative TB targets in the literature, the identification and characterization of the most probable therapeutic targets that influence the complex infectious disease, primarily through interactions with other influenced proteins, remains a statistical and computational challenge in proteomic epidemiology. Protein interaction network analysis provides an effective way to understand the relationships between protein products of genes by interconnecting networks of essential genes and its protein-protein interactions for 5 broad functional categories in Mtb. We also investigated the substru

SUBMITTER: Raman MP 

PROVIDER: S-EPMC3374368 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature