Bisquinolinium compounds induce quadruplex-specific transcriptome changes in HeLa S3 cell lines.

ABSTRACT:

Background

Guanosine rich sequences capable of forming G-quadruplex (G4) motifs are enriched near the gene transcription start site (TSS) in the human genome. When probed at the single gene level, G-quadruplex motifs residing in promoter regions show substantial effects on gene transcription. Moreover, further changes in transcription levels are noticed when G4-motifs are targeted with G-quadruplex-specific small molecules.

Results

Global studies concerning general changes of the transcriptome via targeting promoter-based G-quadruplex motifs are very limited and have so far only been carried out with compounds displaying weak selectivity for quadruplex sequences. Here we utilize two G-quadruplex-specific bisquinolinium derivatives PhenDC3 and 360A and investigate their effec

SUBMITTER: Halder R 

PROVIDER: S-EPMC3375199 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature