THINK Back: KNowledge-based Interpretation of High Throughput data.

ABSTRACT: Results of high throughput experiments can be challenging to interpret. Current approaches have relied on bulk processing the set of expression levels, in conjunction with easily obtained external evidence, such as co-occurrence. While such techniques can be used to reason probabilistically, they are not designed to shed light on what any individual gene, or a network of genes acting together, may be doing. Our belief is that today we have the information extraction ability and the computational power to perform more sophisticated analyses that consider the individual situation of each gene. The use of such techniques should lead to qualitatively superior results. The specific aim of this project is to develop computational techniques to generate a small number of biologically meaningful h

SUBMITTER: Farfan F 

PROVIDER: S-EPMC3375631 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature