Change-point analysis of paired allele-specific copy number variation data.

ABSTRACT: The recent genome-wide allele-specific copy number variation data enable us to explore two types of genomic information including chromosomal genotype variations as well as DNA copy number variations. For a cancer study, it is common to collect data for paired normal and tumor samples. Then, two types of paired data can be obtained to study a disease subject. However, there is a lack of methods for a simultaneous analysis of these four sequences of data. In this study, we propose a statistical framework based on the change-point analysis approach. The validity and usefulness of our proposed statistical framework are demonstrated through the simulation studies and applications based on an experimental data set.

SUBMITTER: Lai Y 

PROVIDER: S-EPMC3375654 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature