Bioactive bromophycolides R-U from the Fijian red alga Callophycus serratus.

ABSTRACT: Four new bromophycolides, R-U (1-4), were isolated from the Fijian red alga Callophycus serratus and were identified by 1D and 2D NMR and mass spectroscopic analyses. These compounds expand the known structural variety of diterpene-benzoate macrolides and exhibited modest cytotoxicity toward selected human cancer cell lines. Bromophycolide S (2) also showed submicromolar activity against the human malaria parasite Plasmodium falciparum.

SUBMITTER: Lin AS 

PROVIDER: S-EPMC3375676 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature