Effect of IL12A and IL12B polymorphisms on the risk of Chlamydia trachomatis-induced tubal factor infertility and disease severity.

ABSTRACT:

Background

Interleukin-12 (IL-12) and related cytokines induce activation and differentiation of T cells. Our aim was to investigate the associations between genetic differences in IL-12-family cytokines and the pathogenesis of chlamydial disease.

Methods

The final study population consisted of 100 women with Chlamydia trachomatis-induced tubal factor infertility (TFI) and 125 pregnant women as controls. Three single nucleotide polymorphisms (SNPs) of IL12A and seven SNPs of IL12B genes were determined from isolated DNA using the Sequenom system with matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry.

Results

We found that the IL12B SNP rs3212227 was associated with both susceptibility and severity of TFI. The minor allele C was r

SUBMITTER: Ohman H 

PROVIDER: S-EPMC3376158 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature