Bone morphogenetic protein modulator BMPER is highly expressed in malignant tumors and controls invasive cell behavior.

ABSTRACT: Bone morphogenetic proteins (BMPs) are growth factors that exert important functions in cell proliferation, migration and differentiation. Till date, multiple human tumors have been reported to display a dysregulation of several members of the BMP pathway that is associated with enhanced malignant tumor growth and metastasis. BMPER (BMP endothelial cell precursor-derived regulator) is a direct BMP modulator that is necessary for BMPs to exert their full-range signaling activity. Moreover, BMPER is expressed by endothelial cells and their progenitors, and has pro-angiogenic features in these cells. Here, we describe the expression of BMPER in human specimens of lung, colon and cervix carcinomas and cell lines derived from such carcinomas. In contrast to healthy tissues, BMPER is highly expr

SUBMITTER: Heinke J 

PROVIDER: S-EPMC3376172 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature