Whole-genome studies identify solute carrier transporters in cellular susceptibility to paclitaxel.

ABSTRACT:

Objective

The clinical use of paclitaxel is limited by variable responses and the potential for significant toxicity. To date, studies of associations between variants in candidate genes and paclitaxel effects have yielded conflicting results. We aimed to evaluate the relationships between global gene expression and paclitaxel sensitivity.

Methods

We utilized well-genotyped lymphoblastoid cell lines derived from the International HapMap Project to evaluate the relationships between cellular susceptibility to paclitaxel and global gene expression. Cells were exposed to varying concentrations of paclitaxel to evaluate paclitaxel-induced cytotoxicity and apoptosis. Among the top genes, we identified solute carrier (SLC) genes associated with paclitaxel sensitivity and narrowed

SUBMITTER: Njiaju UO 

PROVIDER: S-EPMC3376193 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature