Ontology highlight
ABSTRACT:
SUBMITTER: Jackson JG
PROVIDER: S-EPMC3376352 | biostudies-literature | 2012 Jun
REPOSITORIES: biostudies-literature
Cancer cell 20120601 6
Studies on the role of TP53 mutation in breast cancer response to chemotherapy are conflicting. Here, we show that, contrary to dogma, MMTV-Wnt1 mammary tumors with mutant p53 exhibited a superior clinical response compared to tumors with wild-type p53. Doxorubicin-treated p53 mutant tumors failed to arrest proliferation, leading to abnormal mitoses and cell death, whereas p53 wild-type tumors arrested, avoiding mitotic catastrophe. Senescent tumor cells persisted, secreting senescence-associate ...[more]