Aortic valve calcium independently predicts coronary and cardiovascular events in a primary prevention population.

ABSTRACT:

Objectives

This study sought to test whether aortic valve calcium (AVC) is independently associated with coronary and cardiovascular events in a primary-prevention population.

Background

Aortic sclerosis is associated with increased cardiovascular morbidity and mortality among the elderly, but the mechanisms underlying this association remain controversial. Also, it is unknown whether this association extends to younger individuals.

Methods

We performed a prospective analysis of 6,685 participants in MESA (Multi-Ethnic Study of Atherosclerosis). All subjects, ages 45 to 84 years and free of clinical cardiovascular disease at baseline, underwent computed tomography for AVC and coronary artery calcium scoring. The primary, pre-specified combined endpoint of cardiovascul

SUBMITTER: Owens DS 

PROVIDER: S-EPMC3376353 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature