Multidrug resistance-linked gene signature predicts overall survival of patients with primary ovarian serous carcinoma.

ABSTRACT:

Purpose

This study assesses the ability of multidrug resistance (MDR)-associated gene expression patterns to predict survival in patients with newly diagnosed carcinoma of the ovary. The scope of this research differs substantially from that of previous reports, as a very large set of genes was evaluated whose expression has been shown to affect response to chemotherapy.

Experimental design

We applied a customized TaqMan low density array, a highly sensitive and specific assay, to study the expression profiles of 380 MDR-linked genes in 80 tumor specimens collected at initial surgery to debulk primary serous carcinoma. The RNA expression profiles of these drug resistance genes were correlated with clinical outcomes.

Results

Leave-one-out cross-validation was used to e

SUBMITTER: Gillet JP 

PROVIDER: S-EPMC3376649 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature