Serum 25-hydroxyvitamin D and Ethnic Differences in Arterial Stiffness and Endothelial Function.

ABSTRACT:

Background

Vitamin D reportedly influences vascular function, which is worse in African Americans (AAs) relative to European Americans (EAs). It is not clear if ethnic differences in 25(OH)D mediate differences in vascular function. This study examined the relationships of serum 25-hydroxyvitamin D (25(OH)D) with indicators of vascular function among healthy, young AA and EA adults.

Methods

This is a cross sectional study involving 23 AAs and 22 EAs. The main outcomes were augmentation index (AIx75), central aortic pressure, pulse wave velocity (PWV), flow-mediated dilation (FMD), and seated and supine blood pressures.

Results

Results indicated that 25(OH)D was inversely associated with AIx75, supine systolic blood pressure (SBP), central aortic SBP and central aortic

SUBMITTER: Alvarez JA 

PROVIDER: S-EPMC3376878 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature