Ontology highlight
ABSTRACT:
SUBMITTER: Maschler S
PROVIDER: S-EPMC3377343 | biostudies-literature | 2010 Oct
REPOSITORIES: biostudies-literature
EMBO molecular medicine 20101001 10
Metastasis is the major cause of carcinoma-induced death, but mechanisms involved are poorly understood. Metastasis crucially involves epithelial-to-mesenchymal transition (EMT), causing loss of epithelial polarity. Here we identify Annexin A1 (AnxA1), a protein with important functions in intracellular vesicle trafficking, as an efficient suppressor of EMT and metastasis in breast cancer. AnxA1 levels were strongly reduced in EMT of mammary epithelial cells, in metastatic murine and human cell ...[more]