Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits.

ABSTRACT: The gastrointestinal tract harbors a complex and diverse microbiota that has an important role in host metabolism. Microbial diversity is influenced by a combination of environmental and host genetic factors and is associated with several polygenic diseases. In this study we combined next-generation sequencing, genetic mapping, and a set of physiological traits of the BXD mouse population to explore genetic factors that explain differences in gut microbiota and its impact on metabolic traits. Molecular profiling of the gut microbiota revealed important quantitative differences in microbial composition among BXD strains. These differences in gut microbial composition are influenced by host-genetics, which is complex and involves many loci. Linkage analysis defined Quantitative Trait Loci (Q

SUBMITTER: McKnite AM 

PROVIDER: S-EPMC3377628 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature