Stromal genes add prognostic information to proliferation and histoclinical markers: a basis for the next generation of breast cancer gene signatures.

ABSTRACT:

Background

First-generation gene signatures that identify breast cancer patients at risk of recurrence are confined to estrogen-positive cases and are driven by genes involved in the cell cycle and proliferation. Previously we induced sets of stromal genes that are prognostic for both estrogen-positive and estrogen-negative samples. Creating risk-management tools that incorporate these stromal signatures, along with existing proliferation-based signatures and established clinicopathological measures such as lymph node status and tumor size, should better identify women at greatest risk for metastasis and death.

Methodology/principal findings

To investigate the strength and independence of the stromal and proliferation factors in estrogen-positive and estrogen-negative patien

SUBMITTER: Mefford D 

PROVIDER: S-EPMC3377707 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature