CD105 (Endoglin) exerts prognostic effects via its role in the microvascular niche of paediatric high grade glioma.

ABSTRACT: Paediatric high grade glioma (pHGG) (World Health Organisation astrocytoma grades III and IV) remains poor prognosis tumours, with a median survival of only 15 months following diagnosis. Current investigation of anti-angiogenic strategies has focused on adult glioblastoma multiforme (GBM) with phase III trials targeting vascular endothelial growth factor continuing. In this study we investigated whether the degree of vascularity correlated with prognosis in a large cohort of pHGG (n = 150) and whether different vessel markers carried different prognostic value. We found that CD105 (endoglin) had a strongly significant association with poor prognosis on multivariate analysis (p = <0.001). Supervised hierarchical clustering of genome wide gene expression data identified 13 genes associated

SUBMITTER: Smith SJ 

PROVIDER: S-EPMC3377898 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature