Differentiation of African components of ancestry to stratify groups in a case-control study of a Brazilian urban population.

ABSTRACT:

Background

Balancing the subject composition of case and control groups to create homogenous ancestries between each group is essential for medical association studies.

Methods

We explored the applicability of single-tube 34-plex ancestry informative markers (AIM) single nucleotide polymorphisms (SNPs) to estimate the African Component of Ancestry (ACA) to design a future case-control association study of a Brazilian urban sample.

Results

One hundred eighty individuals (107 case group; 73 control group) self-described as white, brown-intermediate or black were selected. The proportions of the relative contribution of a variable number of ancestral population components were similar between case and control groups. Moreover, the case and control groups demonstrated sim

SUBMITTER: Silbiger VN 

PROVIDER: S-EPMC3378015 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature