Ovarian reserve status in young women is associated with altered gene expression in membrana granulosa cells.

ABSTRACT: Diminished ovarian reserve (DOR) is a challenging diagnosis of infertility, as there are currently no tests to predict who may become affected with this condition, or at what age. We designed the present study to compare the gene expression profile of membrana granulosa cells from young women affected with DOR with those from egg donors of similar age and to determine if distinct genetic patterns could be identified to provide insight into the etiology of DOR. Young women with DOR were identified based on FSH level in conjunction with poor follicular development during an IVF cycle (n = 13). Egg donors with normal ovarian reserve (NOR) comprised the control group (n = 13). Granulosa cells were collected following retrieval, RNA was extracted and microarray analysis was conducted to evaluat

SUBMITTER: Skiadas CC 

PROVIDER: S-EPMC3378309 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature