Investigating the role of the coronary vasculature in the mechanisms of defibrillation.

ABSTRACT:

Background

The direct role of coronary vessels in defibrillation, although hypothesized to be important, remains to be elucidated. We investigated how vessel-induced virtual electrode polarizations assist reentry termination.

Methods and results

A highly anatomically detailed rabbit ventricular slice bidomain computer model was constructed from 25-μm magnetic resonance data, faithfully representing both structural and electric properties of blood vessels. For comparison, an equivalent simplified model with intramural cavities filled in was also built. Following fibrillation induction, 6 initial states were selected, and biphasic shocks (5-70 V) were applied using a realistic implanted cardioverter-defibrillator electrode configuration. A fundamental mechanism of biphasic def

SUBMITTER: Bishop MJ 

PROVIDER: S-EPMC3378488 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature