HPV genotype distribution in cervical intraepithelial neoplasia among HIV-infected women in Pune, India.

ABSTRACT:

Background

The distribution of HPV genotypes, their association with rigorously confirmed cervical precancer endpoints, and factors associated with HPV infection have not been previously documented among HIV-infected women in India. We conducted an observational study to expand this evidence base in this population at high risk of cervical cancer.

Methods

HIV-infected women (N = 278) in Pune, India underwent HPV genotyping by Linear Array assay. Cervical intraepithelial neoplasia (CIN) disease ascertainment was maximized by detailed assessment using cytology, colposcopy, and histopathology and a composite endpoint.

Results

CIN2+ was detected in 11.2% while CIN3 was present in 4.7% participants. HPV genotypes were present in 52.5% (146/278) and 'carcinogenic' HPV genot

SUBMITTER: Mane A 

PROVIDER: S-EPMC3378535 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature