Alopecia in a viable phospholipase C delta 1 and phospholipase C delta 3 double mutant.

ABSTRACT:

Background

Inositol 1,4,5trisphosphate (IP(3)) and diacylglycerol (DAG) are important intracellular signalling molecules in various tissues. They are generated by the phospholipase C family of enzymes, of which phospholipase C delta (PLCD) forms one class. Studies with functional inactivation of Plcd isozyme encoding genes in mice have revealed that loss of both Plcd1 and Plcd3 causes early embryonic death. Inactivation of Plcd1 alone causes loss of hair (alopecia), whereas inactivation of Plcd3 alone has no apparent phenotypic effect. To investigate a possible synergy of Plcd1 and Plcd3 in postnatal mice, novel mutations of these genes compatible with life after birth need to be found.

Methodology/principal findings

We characterise a novel mouse mutant with a spontaneously

SUBMITTER: Runkel F 

PROVIDER: S-EPMC3378570 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature