Immunodominant antigens of Leishmania chagasi associated with protection against human visceral leishmaniasis.

ABSTRACT:

Background

Protection and recovery from visceral leishmaniasis (VL) have been associated with cell-mediated immune (CMI) responses, whereas no protective role has been attributed to humoral responses against specific parasitic antigens. In this report, we compared carefully selected groups of individuals with distinct responses to Leishmania chagasi to explore antigen-recognizing IgG present in resistant individuals.

Methodology and principal findings

VL patients with negative delayed-type hypersensitivity (DTH) were classified into the susceptible group. Individuals who had recovered from VL and converted to a DTH+ response, as well as asymptomatic infected individuals (DTH+), were categorized into the resistant group. Sera from these groups were used to detect antigens fro

SUBMITTER: Abanades DR 

PROVIDER: S-EPMC3378602 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature