Ontology highlight
ABSTRACT:
SUBMITTER: Luc S
PROVIDER: S-EPMC3378629 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Nature immunology 20120219 4
The stepwise commitment from hematopoietic stem cells in the bone marrow to T lymphocyte-restricted progenitors in the thymus represents a paradigm for understanding the requirement for distinct extrinsic cues during different stages of lineage restriction from multipotent to lineage-restricted progenitors. However, the commitment stage at which progenitors migrate from the bone marrow to the thymus remains unclear. Here we provide functional and molecular evidence at the single-cell level that ...[more]