Mouse SPNS2 functions as a sphingosine-1-phosphate transporter in vascular endothelial cells.

ABSTRACT: Sphingosine-1-phosphate (S1P), a sphingolipid metabolite that is produced inside the cells, regulates a variety of physiological and pathological responses via S1P receptors (S1P1-5). Signal transduction between cells consists of three steps; the synthesis of signaling molecules, their export to the extracellular space and their recognition by receptors. An S1P concentration gradient is essential for the migration of various cell types that express S1P receptors, such as lymphocytes, pre-osteoclasts, cancer cells and endothelial cells. To maintain this concentration gradient, plasma S1P concentration must be at a higher level. However, little is known about the molecular mechanism by which S1P is supplied to extracellular environments such as blood plasma. Here, we show that SPNS2 function

SUBMITTER: Hisano Y 

PROVIDER: S-EPMC3379171 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature