β-cell function preservation after 3.5 years of intensive diabetes therapy.

ABSTRACT:

Objective

To assess β-cell function preservation after 3.5 years of intensive therapy with insulin plus metformin (INS group) versus triple oral therapy (TOT group) with metformin, glyburide, and pioglitazone.

Research design and methods

This was a randomized trial of 58 patients with treatment-naïve newly diagnosed type 2 diabetes. All patients were treated with insulin and metformin for a 3-month lead-in period followed by random assignment to the INS or TOT group. β-Cell function was assessed using a mixed-meal challenge test at randomization and 6, 12, 18, 30, and 42 months. Analyses were intention to treat and performed with repeated-measures models.

Results

Completion rates at 3.5 years were 83% in the insulin group and 72% in the TOT group, with good compliance

SUBMITTER: Harrison LB 

PROVIDER: S-EPMC3379585 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature