Intensive glycemic control is not associated with fractures or falls in the ACCORD randomized trial.

ABSTRACT:

Objective

Older adults with type 2 diabetes are at high risk of fractures and falls, but the effect of glycemic control on these outcomes is unknown. To determine the effect of intensive versus standard glycemic control, we assessed fractures and falls as outcomes in the Action to Control Cardiovascular Risk in Diabetes (ACCORD) randomized trial.

Research design and methods

ACCORD participants were randomized to intensive or standard glycemia strategies, with an achieved median A1C of 6.4 and 7.5%, respectively. In the ACCORD BONE ancillary study, fractures were assessed at 54 of the 77 ACCORD clinical sites that included 7,287 of the 10,251 ACCORD participants. At annual visits, 6,782 participants were asked about falls in the previous year.

Results

During an average

SUBMITTER: Schwartz AV 

PROVIDER: S-EPMC3379596 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature