Dataset Information
Activating KIR/HLA complexes in classic Kaposi's Sarcoma.
Ontology highlight
ABSTRACT: Background
Classic Kaposi's Sarcoma (cKS) is a rare vascular tumor associated with Human Herpesvirus 8 (KSHV) infection, nevertheless not all KSHV-infected individuals have cKS.Objective
We investigated whether particular KIR/HLA receptor/ligand genotypes would be preferentially present in KSHV-infected and uninfected individuals who have or have not developed cKS.Methods
KIR/HLA genotypes were analyzed by molecular genotyping in 50 KSHV-infected individuals who did or did not have cKS and in 33 age-and sex-matched KSHV seronegative individuals.Results
There was no association of individual KIR, HLA or receptor ligand combinations with KSHV infection. However, activating KIR and KIR/HLA genotypes were significantly more frequent in cKS cases, specifically KIR3DS1, KIR2DS1, and KIR2DS1 with its HLA-C2 ligand.Conclusion
A nonspecific inflammatory response triggered by activation of NK cells upon KIR-HLA interaction could be associated with the pathogenesis of KS.
SUBMITTER: Guerini FR
PROVIDER: S-EPMC3379936 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Publications
Activating KIR/HLA complexes in classic Kaposi's Sarcoma.
Infectious agents and cancer 20120402
<h4>Background</h4>Classic Kaposi's Sarcoma (cKS) is a rare vascular tumor associated with Human Herpesvirus 8 (KSHV) infection, nevertheless not all KSHV-infected individuals have cKS.<h4>Objective</h4>We investigated whether particular KIR/HLA receptor/ligand genotypes would be preferentially present in KSHV-infected and uninfected individuals who have or have not developed cKS.<h4>Methods</h4>KIR/HLA genotypes were analyzed by molecular genotyping in 50 KSHV-infected individuals who did or di ...[more]