Identification and validation of Ifit1 as an important innate immune bottleneck.

ABSTRACT: The innate immune system plays important roles in a number of disparate processes. Foremost, innate immunity is a first responder to invasion by pathogens and triggers early defensive responses and recruits the adaptive immune system. The innate immune system also responds to endogenous damage signals that arise from tissue injury. Recently it has been found that innate immunity plays an important role in neuroprotection against ischemic stroke through the activation of the primary innate immune receptors, Toll-like receptors (TLRs). Using several large-scale transcriptomic data sets from mouse and mouse macrophage studies we identified targets predicted to be important in controlling innate immune processes initiated by TLR activation. Targets were identified as genes with high betweennes

SUBMITTER: McDermott JE 

PROVIDER: S-EPMC3380000 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature