The regulation of vascular endothelial growth factor by hypoxia and prostaglandin F₂α during human endometrial repair.

ABSTRACT:

Context

The human endometrium has an exceptional capacity for repeated repair after menses, but its regulation remains undefined. Premenstrually, progesterone levels fall and prostaglandin (PG) F₂α synthesis increases, causing spiral arteriole constriction. We hypothesized that progesterone withdrawal, PGF₂α, and hypoxia increase vascular endothelial growth factor (VEGF), an endometrial repair factor.

Design and results

Endometrial biopsies were collected (n = 47) with ethical approval and consent. VEGF mRNA, quantified by quantitative RT-PCR, was increased during menstruation (P < 0.01).VEGF protein was maximally secreted from proliferative endometrial explants. Treatment of an endometrial epithelial cell line and primary human endometrial stromal cells with 100 nm PGF₂α or

SUBMITTER: Maybin JA 

PROVIDER: S-EPMC3380090 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature