In silico analysis identifies a novel role for androgens in the regulation of human endometrial apoptosis.

ABSTRACT:

Context

The endometrium is a multicellular, steroid-responsive tissue that undergoes dynamic remodeling every menstrual cycle in preparation for implantation and, in absence of pregnancy, menstruation. Androgen receptors are present in the endometrium.

Objective

The objective of the study was to investigate the impact of androgens on human endometrial stromal cells (hESC).

Design

Bioinformatics was used to identify an androgen-regulated gene set and processes associated with their function. Regulation of target genes and impact of androgens on cell function were validated using primary hESC.

Setting

The study was conducted at the University Research Institute.

Patients

Endometrium was collected from women with regular menses; tissues were used for recove

SUBMITTER: Marshall E 

PROVIDER: S-EPMC3380091 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature