Whole genome expression differences in human left and right atria ascertained by RNA sequencing.

ABSTRACT:

Background

The left and right atria have different susceptibilities toward developing arrhythmias, with left atrial arrhythmias more commonly observed. To understand the molecular basis for such differences, we catalogued micro (mi)RNA and mRNA expression differences by next generation sequencing.

Methods and results

Four human left-right atrial pairs were subjected to whole-genome expression analyses via next-generation sequencing of small RNAs, including miRNAs, and poly-A-enriched mRNAs. Using a paired sample design, significant differences in the expression of 32 miRNAs were found in between the left and right atria at a probability value of <0.01. Hsa-miR-143 was the most highly expressed miRNA in the atria, as quantified by RNA sequencing. There were 746 and 2292 diffe

SUBMITTER: Hsu J 

PROVIDER: S-EPMC3380143 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature