Peptide targeting of adenoviral vectors to augment tumor gene transfer.

ABSTRACT: Adenovirus serotype 5 remains one of the most promising vectors for delivering genetic material to cancer cells for imaging or therapy, but optimization of these agents to selectively promote tumor cell infection is needed to further their clinical development. Peptide sequences that bind to specific cell surface receptors have been inserted into adenoviral capsid proteins to improve tumor targeting, often in the background of mutations designed to ablate normal ligand:receptor interactions and thereby reduce off target effects and toxicities in non-target tissues. Different tumor types also express highly variable complements of cell surface receptors, so a customized targeting strategy using a particular peptide in the context of specific adenoviral mutations may be needed to achieve opt

SUBMITTER: Ballard EN 

PROVIDER: S-EPMC3380173 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature