Liver hyperplasia after tamoxifen induction of Myc in a transgenic medaka model.

ABSTRACT: Myc is a global transcriptional regulator and one of the most frequently overexpressed oncoproteins in human tumors. It is well established that activation of Myc leads to enhanced cell proliferation but can also lead to increased apoptosis. The use of animal models expressing deregulated levels of Myc has helped to both elucidate its function in normal cells and give insight into how Myc initiates and maintains tumorigenesis. Analyses of the medaka (Oryzias latipes) genome uncovered the unexpected presence of two Myc gene copies in this teleost species. Comparison of these Myc versions to other vertebrate species revealed that one gene, myc17, differs by the loss of some conserved regulatory protein motifs present in all other known Myc genes. To investigate how such differences might aff

SUBMITTER: Menescal LA 

PROVIDER: S-EPMC3380712 | biostudies-literature | 2012 Jul

REPOSITORIES: biostudies-literature