Prediction of heme binding residues from protein sequences with integrative sequence profiles.

ABSTRACT:

Background

The heme-protein interactions are essential for various biological processes such as electron transfer, catalysis, signal transduction and the control of gene expression. The knowledge of heme binding residues can provide crucial clues to understand these activities and aid in functional annotation, however, insufficient work has been done on the research of heme binding residues from protein sequence information.

Methods

We propose a sequence-based approach for accurate prediction of heme binding residues by a novel integrative sequence profile coupling position specific scoring matrices with heme specific physicochemical properties. In order to select the informative physicochemical properties, we design an intuitive feature selection scheme by combining a greed

SUBMITTER: Xiong Y 

PROVIDER: S-EPMC3380730 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature