Protein surface representation and analysis by dimension reduction.

ABSTRACT:

Background

Protein structures are better conserved than protein sequences, and consequently more functional information is available in structures than in sequences. However, proteins generally interact with other proteins and molecules via their surface regions and a backbone-only analysis of protein structures may miss many of the functional and evolutionary features. Surface information can help better elucidate proteins' functions and their interactions with other proteins. Computational analysis and comparison of protein surfaces is an important challenge to overcome to enable efficient and accurate functional characterization of proteins.

Methods

In this study we present a new method for representation and comparison of protein surface features. Our method is based on

SUBMITTER: Yang H 

PROVIDER: S-EPMC3380731 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature