IDDI: integrated domain-domain interaction and protein interaction analysis system.

ABSTRACT:

Background

Deciphering protein-protein interaction (PPI) in domain level enriches valuable information about binding mechanism and functional role of interacting proteins. The 3D structures of complex proteins are reliable source of domain-domain interaction (DDI) but the number of proven structures is very limited. Several resources for the computationally predicted DDI have been generated but they are scattered in various places and their prediction show erratic performances. A well-organized PPI and DDI analysis system integrating these data with fair scoring system is necessary.

Method

We integrated three structure-based DDI datasets and twenty computationally predicted DDI datasets and constructed an interaction analysis system, named IDDI, which enables to browse prote

SUBMITTER: Kim Y 

PROVIDER: S-EPMC3380739 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature