Genetic ancestry-smoking interactions and lung function in African Americans: a cohort study.

ABSTRACT:

Background

Smoking tobacco reduces lung function. African Americans have both lower lung function and decreased metabolism of tobacco smoke compared to European Americans. African ancestry is also associated with lower pulmonary function in African Americans. We aimed to determine whether African ancestry modifies the association between smoking and lung function and its rate of decline in African Americans.

Methodology/principal findings

We evaluated a prospective ongoing cohort of 1,281 African Americans participating in the Health, Aging, and Body Composition (Health ABC) Study initiated in 1997. We also examined an ongoing prospective cohort initiated in 1985 of 1,223 African Americans in the Coronary Artery Disease in Young Adults (CARDIA) Study. Pulmonary function and

SUBMITTER: Aldrich MC 

PROVIDER: S-EPMC3380861 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature