Kisspeptin-10 is a potent stimulator of LH and increases pulse frequency in men.

ABSTRACT:

Context

Kisspeptins stimulate GnRH and thus gonadotropin secretion. Kisspeptin-10 is the minimal kisspeptin sequence with full intrinsic bioactivity, but it has not been studied in man.

Objective

We investigated our hypothesis that kisspeptin-10 increases GnRH and thus LH pulse frequency.

Design and participants

The dose response of kisspeptin-10 was investigated by administering iv bolus doses (0.01-3.0 μg/kg) and vehicle to healthy men. Effects on LH pulse frequency and size were determined by deconvolution analysis during infusion of kisspeptin-10 for up to 22.5 h.

Results

Intravenous bolus kisspeptin-10 resulted in a rapid and dose-dependent rise in serum LH concentration, with maximal stimulation at 1 μg/kg (4.1 ± 0.4 to 12.4 ± 1.7 IU/liter at 30 min, P <

SUBMITTER: George JT 

PROVIDER: S-EPMC3380939 | biostudies-literature | 2011 Aug

REPOSITORIES: biostudies-literature