Common TGFβ2, BMP4, and FOXC1 variants are not associated with primary open-angle glaucoma.

ABSTRACT:

Purpose

Primary open-angle glaucoma (POAG) is a common but complex disease with a strong genetic component. Notably, few genes have been robustly associated with POAG. An obvious group of genes to test as susceptibility factors for POAG are the developmental genes forkhead box C1 (FOXC1), transforming growth factor-beta 2 (TGFβ2), and bone morphogenic protein 4 (BMP4). These genes are known to play important roles in the normal morphogenesis of the anterior segment and/or have been implicated in intra-ocular pressure (IOP) regulation and trabecular meshwork function. This study investigates the role of FOXC1, TGFβ2, and BMP4 in POAG.

Methods

The contribution of common genetic variation at the FOXC1, TGFβ2, and BMP4 loci to risk of POAG was investigated in a case-control asso

SUBMITTER: Park S 

PROVIDER: S-EPMC3380945 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature