Identification of the receptor tyrosine kinase AXL in breast cancer as a target for the human miR-34a microRNA.

ABSTRACT: The identification of molecular features that contribute to the progression of breast cancer can provide valuable insight into the pathogenesis of this disease. Deregulated microRNA expression represents one type of molecular event that has been associated with many different human cancers. In order to identify a miRNA/mRNA regulatory interaction that is biologically relevant to the triple-negative breast cancer genotype/phenotype, we initially conducted a miRNA profiling experiment to detect differentially expressed miRNAs in cell line models representing triple-negative (MDA-MB-231), ER(+) (MCF7), and HER-2 overexpressed (SK-BR-3) histotypes. We identified human miR-34a expression as being >3-fold down (from its median expression value across all cell lines) in MDA-MB-231 cells, and iden

SUBMITTER: Mackiewicz M 

PROVIDER: S-EPMC3381742 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature